Application of Nanobiosensors for Diagnostics of the Acute Coronary Syndrome in Emergency Medicine
( Pp. 322-328)
More about authors
Khasanov Adam A.
Cand. Sci. (Phys.-Math.), Associate Professor, State University of Land Use Planning; Moscow, Russian Federation
Moscow Institute of Physics and Technology (National Research University)
Dolgoprudny, Russian Federation
Moscow Institute of Physics and Technology (National Research University)
Dolgoprudny, Russian Federation
Abstract:
The primary and mandatory tool for the diagnosis of ACS is an electrocardiogram. However, ECG can reliably distinguish only one type of ACS, namely myocardial infarction with ST-segment elevation. MI without ST-segment elevation cannot be detected with aid of ECG but modern medicine employs such instruments as cardiobiomarkers’ concentration measurement in human blood for this. Due to the relatively low, in the range of nanograms per liter, concentrations of biomarkers, such as Troponin I and Troponin T, miniaturized and highly sensitive instruments are needed. With the development of nanotechnology, nanobiosensors are becoming available allowing for the conduction of such research. The present analysis introduces some of the types of nanobiosensors capable of measuring these biomarkers with the required sensitivity and accuracy in human blood plasma.
How to Cite:
Khasanov A.A. Application of nanobiosensors for diagnostics of the acute coronary syndrome in emergency medicine. Computational Nanotechnology. 13, 2 (2026), 322–328. DOI: 10.33693/2313-223X-2026-13-2-322-328. EDN: XCVZIH
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Damien W.M. Arrigan. Nanoelectrodes, nanoelectrode arrays and their applications. 2004. DOI: 10.1039/B415395M.
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Haryanto R., Khairurrijal F., Mitra Kh.D. GMR biosensors for clinical diagnostics. 2011. DOI: 10.5772/16365.
Khanna V.K. Nanosensors physical, chemical, and biological. CRC Press. 2016. P. 666. ISBN: 1439827133, 9781439827130.
Kim K., Kim M.J., Kim D.W. et al. Clinically accurate diagnosis of Alzheimer’s disease via multiplexed sensing of core biomarkers in human plasma. Nat. Commun. 2020. No. 11. P. 119. DOI: 10.1038/s41467-019-13901-z.
Mahajan V.S., Jarolim P. How to interpret elevated cardiac troponin levels. AHA Journals. 2011. DOI: 10.1161/CIRCULATIONAHA.111.023697.
Munawar A., Ong Y., Schirhagl R. et al. Nanosensors for diagnosis with optical, electric and mechanical transducers. RSC Adv. 2019. 6793. DOI: 10.1039/c8ra10144b.
Naira P.R., Alam M.A. Performance limits of nanobiosensors. Appl. Phys. Lett. 2006. Vol. 88. DOI: 10.1063/1.2211310.
Nguyen H.H., Park J., Kang S., Kim M. Surface plasmon resonance: A versatile technique for biosensor applications. Sensors. 2015. Vol. 15. Issue 5. Pp. 10481–10510. DOI: 10.3390/s150510481.
Wang J., Lin W., Cao E. et al. Surface plasmon resonance sensors on raman and fluorescence spectroscopy. Sensors. 2017. No. 17. P. 2719. DOI: 10.3390/s17122719.
Keywords:
acute coronary syndrome, biomarker, nanobiosensors, nanomaterials.
