PROSPECTS FOR THE DEVELOPMENT OF NEW PREPARATION BASED ON THE BIOSYNTHETIC ORGANIC ACIDS FOR THE PREVENTION AND TREATMENT OF HYPOXIA IN A LONG-TERM SPACE MISSIONS
( Pp. 168-171)
More about authors
Allayarov Ramil K.
aspirant
G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences Stepanova Nadezhda N. magistrant
Pushchino State Institute of Natural Sciences Morgunov Grigorii I. student 1 kursa
Institute of Space Technologies of the Peoples’ Friendship University of Russia Kamzolova Svetlana V. kand. biol. nauk, st. nauch. sotrudnik laboratorii aerobnogo metabolizma mikroorganizmov
G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences
G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences Stepanova Nadezhda N. magistrant
Pushchino State Institute of Natural Sciences Morgunov Grigorii I. student 1 kursa
Institute of Space Technologies of the Peoples’ Friendship University of Russia Kamzolova Svetlana V. kand. biol. nauk, st. nauch. sotrudnik laboratorii aerobnogo metabolizma mikroorganizmov
G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences
Abstract:
Background: During the long-term space missions the risk of hypoxic and stress reactions by the space crewmen is developed. It is suggested that succinic acid (SA), α-ketoglutaric acid (KGA), threo-Ds-isocitric acid (ICA) and palmitoleic acid (POA) possess the antihypoxic and antioxidant effects. The bottleneck in the development and practical application of these simple, nontoxic, and moderately priced preparations is the absence of industrial production (not only in Russia but also in the world) of the mentioned organic acids of required quality, which are different from the products of chemical synthesis by natural conformeric and isomeric composition. The aim of this paper is to present modern technologies for microbiological production of target acids which are developed at the Institute of Biochemistry and Physiology of Microorganisms as the basis for the development of the original brand new preparation for the prevention and treatment of hypoxia in astronauts. Materials and methods: The experimental studies on the development of biotechnologies of ICA, KGA and SAfrom rapeseed oil by yeast Yarrowia lipolytica, and the screening of yeast strains to identify potential producers of POA were conducted during this study. Results: The biotechnologies with target concentration of 70 g/L, suitable for industrial realization, were proposed. For the first time it was indicated the principal possibility for microbial synthesis of POA. Conclusions: The results of this study can be used for the development of fundamentally new original preparations based on biosynthetic organic acids for the prevention and treatment of hypoxia in a long-term space missions. The developed technologies have no analogues in Russia and in the world.
How to Cite:
Allayarov R.K., Stepanova N.N., Morgunov G.I., Kamzolova S.V., (2016), PROSPECTS FOR THE DEVELOPMENT OF NEW PREPARATION BASED ON THE BIOSYNTHETIC ORGANIC ACIDS FOR THE PREVENTION AND TREATMENT OF HYPOXIA IN A LONG-TERM SPACE MISSIONS. Business in Law, 6 => 168-171.
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Heinonen I., Kemppainen J., Kaskinoro K., Peltonen J. E., Sipil H. T., Nuutila P.,.. Kalliokoski K. K. Effects of adenosine, exercise, and moderate acute hypoxia on energy substrate utilization of human skeletan muscle // Am. J. Physiol. Regul. Integr. Comp. Physiol. - 2012. - V. 302(3). - P. 385-390.
Heretsch P., Thomas F., Aurich A., Krautscheid H., Sicker D., Giannis A. Syntheses with a chiral building block from the citric acid cycle: (2R,3S)-isocitric acid by fermentation of sunflower oil // Angew. Chem. Int. Ed. Engl. - 2008. - V. 47. - P. 1958-1960.
Huang C. B., George B., Ebersole J. L. Antimicrobial activity of n-6, n-7 and n-9 fatty acids and their esters for oral microorganisms // Arch. Oral Biol. - 2010. - V. 55. - P. 555 - 560.
Kamzolova S.V., Dedyukhina E.G., Samoilenko V.A., Lunina J.N., Puntus I.F., Allayarov R.K., Chiglintseva M.N., Mironov A.A., and Morgunov I.G. Isocitric acid production from rapeseed oil by Yarrowia lipolytica yeast // Appl. Microbiol. Biotechnol. - 2013. - Vol. 97. - P. 9133-9144.
Kamzolova S.V., Morgunov I.G. -Ketoglutaric acid production from rapeseed oil by Yarrowia lipolytica yeast // Appl. Microbiol. Biotechnol. - 2013. - Vol. 97. - P. 5517-5525.
Kamzolova S.V., Vinokurova N.G., Dedyukhina E.G., Samoilenko V.A., Lunina J.N., Mironov A.A., Allayarov R.K., Morgunov I.G. The peculiarities of succinic acid production from rapeseed oil by Yarrowia lipolytica yeast // Appl. Microbiol. Biotechnol. - 2014. - Vol. 98. - № 9. - P. 4149 -4157.
Kondrashova M.N., Maevsky E.L., Grigorenko E.V., Babsky A.M., Doliba N.M., Saakyan I.R., Sirota T.V., Fedotcheva N.I. The interaction of Krebs cycle with sympathetic and parasympathetic nervous system. Substrate-hormonal system // Abstracts of International Conference on Mitochondria, from Molecular Insight to Physiology and Pathology. Bari, Italy, 2005, p. 74.
McKinaly J.B., Vieille C., Zeikus J.G. Prospects for a bio-based succinate industry // Appl. Microbiol. Biotechnol. - 2007. - V. 76. - P. 727-740.
Stottmeister U., Aurich A., Wilde H., Andersch J., Schmidt S., Sicker D. White biotechnology for Green chemistry: fermentative 2-oxocarboxylic acids as novel building blocks for subsequent chemical syntheses // J. Ind. Microbiol. Biotech. - 2005. - V. 32. - P. 651-664.
Wotring V.E. Medication use by U.S. crewmembers on the International Space Station // Faseb J. - 2015. - V. 29. - № 11. - P. 4417-4423.
Wu Y., Li R., Hildebrand D. F. Biosynthesis and metabolic engineering of palmitoleate production, an important contributor to human health and sustainable // Prog. Lipid Res. - 2012. - V. 51. - P. 340-349.
Keywords:
space research, hypoxia, antihypoxic, microbial synthesis, organic acids.
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